Population Pharmacokinetics and Pharmacogenetics of Mycophenolic Acid Following Administration of Mycophenolate Mofetil in De Novo Pediatric Renal‐Transplant Patients

@article{Zhao2010PopulationPA,
  title={Population Pharmacokinetics and Pharmacogenetics of Mycophenolic Acid Following Administration of Mycophenolate Mofetil in De Novo Pediatric Renal‐Transplant Patients},
  author={W. Zhao and M. Fakhoury and G. Desch{\^e}nes and G. Roussey and K. Brochard and P. Niaudet and M. Tsimaratos and J. Andr{\'e} and S. Cloarec and P. Cochat and A. Bensman and S. Azougagh and E. Jacqz-Aigrain},
  journal={The Journal of Clinical Pharmacology},
  year={2010},
  volume={50}
}
The objective was to develop a population pharmacokinetic‐pharmacogenetic model of mycophenolic acid following administration of mycophenolate mofetil (MMF) in de novo pediatric renal‐transplant patients and identify factors that explain variability. The pharmacokinetic samples were collected from 89 de novo pediatric renal‐transplant patients treated with MMF and studied during the first 60 postoperative days. All patients were genotyped for UGT1A8–A9, UGT2B7, and ABCC2. Population… Expand
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References

SHOWING 1-10 OF 60 REFERENCES
Population Pharmacokinetics of Mycophenolic Acid in Kidney Transplant Pediatric and Adolescent Patients
  • 51
Sirolimus Population Pharmacokinetic/Pharmacogenetic Analysis and Bayesian Modelling in Kidney Transplant Recipients
  • 58
Time-dependent clearance of mycophenolic acid in renal transplant recipients.
  • 57
  • Highly Influential
...
1
2
3
4
5
...