Population Pharmacokinetic-Pharmacodynamic Modelling of Angiotensin Receptor Blockade in Healthy Volunteers

@article{Csajka2002PopulationPM,
  title={Population Pharmacokinetic-Pharmacodynamic Modelling of Angiotensin Receptor Blockade in Healthy Volunteers},
  author={Chantal Csajka and Thierry Buclin and Karin E. Fattinger and Hans Rudolf Brunner and Jérôme Biollaz},
  journal={Clinical Pharmacokinetics},
  year={2002},
  volume={41},
  pages={137-152}
}
ObjectiveTo compare the pharmacokinetic and pharmacodynamic characteristics of angiotensin II receptor antagonists as a therapeutic class.DesignPopulation pharmacokinetic-pharmacodynamic modelling study.MethodsThe data of 14 phase I studies with 10 different drugs were analysed. A common population pharmacokinetic model (two compartments, mixed zero- and first-order absorption, two metabolite compartments) was applied to the 2685 drug and 900 metabolite concentration measurements. A standard… 
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24 Citations

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The aim of the present review is to describe the current knowledge of PK/PD modeling of antihypertensive drugs in basic and clinical research and its future applications.

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Population Pharmacokinetic Modeling of Olmesartan, the Active Metabolite of Olmesartan Medoxomil, in Patients with Hypertension

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Application of the population approach, using nonlinear mixed effects modeling (NONMEM), showed that this methodology is suitable to quantify the average parameters that describe the 24-hour SBP profile as well as the amount of variability between patients in these parameters.

Evaluation of Population Pharmacokinetics and Exposure‐Response Relationship With Coadministration of Amlodipine Besylate and Olmesartan Medoxomil

Population pharmacokinetic models for amlodipine and olmesartan were developed using data collected from 4 phase I studies in healthy volunteers and 1 phase III study in subjects with mild to severe hypertension and shows that neither agent had a clinically significant impact on the clearance of the other.

The integration of pharmacokinetics and pharmacodynamics: understanding dose-response.

The utility and applications of PK and PD in the study of drugs are explored, examples of lessons learned from their application to studies of human pharmacology are provided, some of their limitations are pointed out, and the thesis that these tools ideally should be employed together in an integrated approach is advanced.

Angiotensin II type 1 receptor 1166A/C polymorphism in association with blood pressure response to exogenous angiotensin II

It is suggested that exogenous human angiotensin II increases the BP more potently in subjects with 1166A/C than in those with 1165A/A, and the relationship between the AT1R1166C/C genotypes and BP responses is studied.

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