Population Pharmacokinetic Modeling of Etoposide Free Concentrations in Solid Tumor


This study aimed to determine free etoposide (ETO) concentrations in two regions of Walker-256 (W256) solid tumor using microdialysis and to establish a population pharmacokinetic (popPK) model to describe simultaneously free tumor and total plasma concentrations. W256 tumor-bearing Wistar rats received ETO 10 or 20 mg/kg i.v. bolus. Free ETO concentrations… (More)
DOI: 10.1007/s11095-016-1906-4

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