Population Pharmacokinetic Analysis of Mizolastine and Validation from Sparse Data on Patients Using the Nonparametric Maximum Likelihood Method

@article{Mesnil1998PopulationPA,
  title={Population Pharmacokinetic Analysis of Mizolastine and Validation from Sparse Data on Patients Using the Nonparametric Maximum Likelihood Method},
  author={Florence Mesnil and France Mentr{\'e} and Catherine Dubruc and J. -P. Thenot and Alain J. Mallet},
  journal={Journal of Pharmacokinetics and Biopharmaceutics},
  year={1998},
  volume={26},
  pages={133-161}
}
A population analysis of the kinetics of mizolastine was performed from concentrations on 449 allergic patients, using the nonparametric maximum likelihood method (NPML). A two-compartment open model with zero-order absorption was used to describe the kinetics of mizolastine after oral administration. A heteroscedastic variance model was assumed for the error. To explain the kinetic variability, eight covariates were introduced in the analysis: gender, pharmaceutical dosage form, age, body… CONTINUE READING
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