Population Genomic Scan for Candidate Signatures of Balancing Selection to Guide Antigen Characterization in Malaria Parasites

@inproceedings{AmambuaNgwa2012PopulationGS,
  title={Population Genomic Scan for Candidate Signatures of Balancing Selection to Guide Antigen Characterization in Malaria Parasites},
  author={Alfred Amambua-Ngwa and Kevin K A Tetteh and Magnus Manske and Natalia Gomez-Escobar and Lindsay B Stewart and M. Elizabeth Deerhake and Ian H. Cheeseman and Christopher I. Newbold and Anthony A. Holder and Ellen Knuepfer and Omar Janha and Muminatou Jallow and Susana G. Campino and Bronwyn Macinnis and Dominic P Kwiatkowski and David J Conway},
  booktitle={PLoS genetics},
  year={2012}
}
Acquired immunity in vertebrates maintains polymorphisms in endemic pathogens, leading to identifiable signatures of balancing selection. To comprehensively survey for genes under such selection in the human malaria parasite Plasmodium falciparum, we generated paired-end short-read sequences of parasites in clinical isolates from an endemic Gambian population, which were mapped to the 3D7 strain reference genome to yield high-quality genome-wide coding sequence data for 65 isolates. A minority… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 1 time over the past 90 days. VIEW TWEETS

Citations

Publications citing this paper.
Showing 1-10 of 56 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 83 references

Identification and functional validation of the novel antimalarial resistance locus PF10_0355 in Plasmodium falciparum

  • D Van Tyne, DJ Park, SF Schaffner, DE Neafsey, E Angelino
  • PLoS Genet
  • 2011
Highly Influential
4 Excerpts

Similar Papers

Loading similar papers…