Population Genomic Inferences from Sparse High-Throughput Sequencing of Two Populations of Drosophila melanogaster

@inproceedings{Sackton2009PopulationGI,
  title={Population Genomic Inferences from Sparse High-Throughput Sequencing of Two Populations of Drosophila melanogaster},
  author={Timothy B. Sackton and Rob J Kulathinal and Casey M. Bergman and Aaron R. Quinlan and Erik B. Dopman and Mauricio O. Carneiro and Gabor T. Marth and Daniel L. Hartl and Andrew G. Clark},
  booktitle={Genome biology and evolution},
  year={2009}
}
Short-read sequencing techniques provide the opportunity to capture genome-wide sequence data in a single experiment. A current challenge is to identify questions that shallow-depth genomic data can address successfully and to develop corresponding analytical methods that are statistically sound. Here, we apply the Roche/454 platform to survey natural variation in strains of Drosophila melanogaster from an African (n = 3) and a North American (n = 6) population. Reads were aligned to the… CONTINUE READING
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