Population Biology of Antigen Presentation by MHC Class I Molecules

@article{Parham1996PopulationBO,
  title={Population Biology of Antigen Presentation by MHC Class I Molecules},
  author={Peter Parham and Tomoko Ohta},
  journal={Science},
  year={1996},
  volume={272},
  pages={67 - 74}
}
In principle, the function of major histocompatibility complex (MHC) molecules is simple: to bind a peptide and engage a T cell. In practice, placing this function within the context of the immune response begs questions of population biology: How does the immune response emerge from the interactions among populations of peptides, T cells, and MHC molecules? Within a population of vertebrates, how does MHC polymorphism stamp individuality on the response? Does polymorphism confer differential… 

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TLDR
The role of the endoplasmic reticulum resident MHC class I chaperone tapasin is examined to assess the multiple functions of tapasin in facilitating peptide loading and a consideration of the molecular mechanisms that may permit such allele specific interactions.

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    Cellular and Molecular Life Sciences CMLS
  • 2004
TLDR
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MHC class I molecules exploit the low G+C content of pathogen genomes for enhanced presentation

TLDR
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...

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