Population Biology of Antigen Presentation by MHC Class I Molecules

@article{Parham1996PopulationBO,
  title={Population Biology of Antigen Presentation by MHC Class I Molecules},
  author={P. Parham and T. Ohta},
  journal={Science},
  year={1996},
  volume={272},
  pages={67 - 74}
}
In principle, the function of major histocompatibility complex (MHC) molecules is simple: to bind a peptide and engage a T cell. In practice, placing this function within the context of the immune response begs questions of population biology: How does the immune response emerge from the interactions among populations of peptides, T cells, and MHC molecules? Within a population of vertebrates, how does MHC polymorphism stamp individuality on the response? Does polymorphism confer differential… Expand

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