Population Biology of Antigen Presentation by MHC Class I Molecules

  title={Population Biology of Antigen Presentation by MHC Class I Molecules},
  author={Peter Parham and Tomoko Ohta},
  pages={67 - 74}
In principle, the function of major histocompatibility complex (MHC) molecules is simple: to bind a peptide and engage a T cell. In practice, placing this function within the context of the immune response begs questions of population biology: How does the immune response emerge from the interactions among populations of peptides, T cells, and MHC molecules? Within a population of vertebrates, how does MHC polymorphism stamp individuality on the response? Does polymorphism confer differential… 

Molecular requirements for assembly and intracellular transport of class I major histocompatibility complex molecules.

Class I molecules are peptide-binding proteins that provide an extracellular representation of intracellular antigen content for inspection by the CD8+ T lymphocytes through interactions of their T cell receptors (TCR) with the class I MHC-peptide complex.

The role of tapasin in MHC class 1 antigen presentation.

The role of the endoplasmic reticulum resident MHC class I chaperone tapasin is examined to assess the multiple functions of tapasin in facilitating peptide loading and a consideration of the molecular mechanisms that may permit such allele specific interactions.

Evolutionary and functional perspectives of the major histocompatibility complex class I antigen-processing machinery

  • K. Paulsson
  • Biology
    Cellular and Molecular Life Sciences CMLS
  • 2004
This review focuses on the functional relationship and evolutionary history of the antigen-processing machinery (APM) components and MHC class I itself, of great interest for further elucidating the origin of the immune system and understanding the mechanisms of antigen presentation and immunology in general.

A Comparative Study of HLA Binding Affinity and Ligand Diversity: Implications for Generating Immunodominant CD8+ T Cell Responses1

HLA-B alleles were found to have a less diverse peptide repertoire, which points toward a more restricted binding motif, and the respective average peptide binding affinity was shown to be lower than that of HLA-A-restricted epitopes, giving rise to new hypotheses concerning the mechanisms underlying immunodominance of CD8+ T cell responses.

Antagonistic effects of a Mhc class I allele on malaria-infected house sparrows.

It is shown that susceptibility alleles may be maintained in a population of house sparrows if they have antagonistic effects on different malaria parasites, and it is suggested that this antagonistic effect might arise because Mhc genes can alter the competitive interactions between malaria parasites within the host.

The impact of MHC diversity on cattle T cell responses.

MHC class I molecules exploit the low G+C content of pathogen genomes for enhanced presentation

The results demonstrate that despite the fast evolution of MHC‐I alleles and their extreme polymorphism and diversity in peptide‐binding preferences, M HC‐I molecules can acquire a preference to exploit pathogen‐specific signatures.



Evolution of the major histocompatibility complex.

This article will summarize what is known about the genetic organization of the Mhc in different species and will discuss the selection pressures acting on the individual loci and the tempo and the mechanisms of their evolution.

Heterozygosity of H–2 loci in wild mice

A similarly high frequency of heterozygosity in the mouse H–2 complex in a population of mice is reported, in spite of a social structure that would tend to reduceheterozygosity.

The foreign antigen binding site and T cell recognition regions of class I histocompatibility antigens

Most of the polymorphic amino acids of the class I histocompatibility antigen, HLA-A2, are clustered on top of the molecule in a large groove identified as the recognition site for processed foreign

Structure, function, and diversity of class I major histocompatibility complex molecules.

This paper presents a model for How TcRs Bind to the Peptide-MHC omplex and discusses the structure of the c~I and e~e Domains, and the role of Peptides that Fit in the Site.

Trans-specific Mhc polymorphism and the origin of species in primates.

The theory of allelic genealogy to the primate Mhc genes is applied and it is indicated that the long-term effective population size of the studied species was between 10(4) and 10(5) individuals and that it most likely never dropped below 10(3) individuals.

Characterization of peptides bound to the class I MHC molecule HLA-A2.1 by mass spectrometry.

Microcapillary high-performance liquid chromatography-electrospray ionization-tandem mass spectrometry was used to fractionate and sequence subpicomolar amounts of peptides isolated from the MHC molecule HLA-A2.1.

Consensus motifs and peptide ligands of MHC class I molecules.

This review discusses the consensus motifs known at present and lists most of the sequences referring to natural MHC-ligands, including two invariant 'anchor' amino acids.

Human leukocyte antigens and natural selection by malaria.

  • A. HillS. Yates M. Plebanski
  • Biology
    Philosophical transactions of the Royal Society of London. Series B, Biological sciences
  • 1994
Analysis of large case-control studies of HLA types in African children with severe malaria indicate that HLA associations with this parasitic infection do exist and it is becoming possible to investigate the underlying mechanisms by identification of peptide epitopes in parasite antigens.