Population-Based in Vitro Hazard and Concentration–Response Assessment of Chemicals: The 1000 Genomes High-Throughput Screening Study

@inproceedings{Abdo2015PopulationBasedIV,
  title={Population-Based in Vitro Hazard and Concentration–Response Assessment of Chemicals: The 1000 Genomes High-Throughput Screening Study},
  author={Nour Abdo and Menghang Xia and Chad E. Brown and Oksana Kosyk and Ruili Huang and Srilatha Sakamuru and Yi-Hui Zhou and John R. Jack and Paul J. Gallins and Kai Xia and Yun Li and Weihsueh A Chiu and Alison A. Motsinger-Reif and Christopher P. Austin and Raymond Richard Tice and Ivan Rusyn and Fred A. Wright},
  booktitle={Environmental health perspectives},
  year={2015}
}
BACKGROUND Understanding of human variation in toxicity to environmental chemicals remains limited, so human health risk assessments still largely rely on a generic 10-fold factor (10½ each for toxicokinetics and toxicodynamics) to account for sensitive individuals or subpopulations. OBJECTIVES We tested a hypothesis that population-wide in vitro cytotoxicity screening can rapidly inform both the magnitude of and molecular causes for interindividual toxicodynamic variability. METHODS We… CONTINUE READING