Population-Based Mechanistic Prediction of Oral Drug Absorption

@article{Jamei2009PopulationBasedMP,
  title={Population-Based Mechanistic Prediction of Oral Drug Absorption},
  author={Masoud Jamei and David B. Turner and Jiansong Yang and Sibylle Neuhoff and Sebastian Polak and Amin Rostami-Hodjegan and Geoffrey T. Tucker},
  journal={The AAPS Journal},
  year={2009},
  volume={11},
  pages={225-237}
}
The bioavailability of drugs from oral formulations is influenced by many physiological factors including gastrointestinal fluid composition, pH and dynamics, transit and motility, and metabolism and transport, each of which may vary with age, gender, race, food, and disease. Therefore, oral bioavailability, particularly of poorly soluble and/or poorly permeable compounds and those that are extensively metabolized, often exhibits a high degree of inter- and intra-individual variability. While… CONTINUE READING
BETA

Figures and Tables from this paper.

Citations

Publications citing this paper.
SHOWING 1-10 OF 134 CITATIONS

A new physiologically based pharmacokinetic model for the prediction of gastrointestinal drug absorption: translocation model.

  • Drug metabolism and disposition: the biological fate of chemicals
  • 2015
VIEW 6 EXCERPTS
CITES BACKGROUND & METHODS
HIGHLY INFLUENCED

Modelling and simulation in bioequivalence

VIEW 10 EXCERPTS
CITES BACKGROUND & METHODS
HIGHLY INFLUENCED

Optimizing the Clinical Use of Carvedilol in Liver Cirrhosis Using a Physiologically Based Pharmacokinetic Modeling Approach

  • European Journal of Drug Metabolism and Pharmacokinetics
  • 2016
VIEW 3 EXCERPTS
CITES BACKGROUND & METHODS
HIGHLY INFLUENCED

FILTER CITATIONS BY YEAR

2009
2019

CITATION STATISTICS

  • 23 Highly Influenced Citations

  • Averaged 17 Citations per year over the last 3 years

References

Publications referenced by this paper.
SHOWING 1-10 OF 133 REFERENCES

The Simcyp population-based ADME simulator.

  • Expert opinion on drug metabolism & toxicology
  • 2009
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

The influence of first pass metabolism on the development and validation of an IVIVC for metoprolol extended release tablets.

  • European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V
  • 2002
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

Absorption-excipient-pH classification gradient maps: sparingly soluble drugs and the pH partition hypothesis.

  • European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
  • 2008

Similar Papers

Loading similar papers…