Population-Based Mechanistic Prediction of Oral Drug Absorption

@article{Jamei2009PopulationBasedMP,
  title={Population-Based Mechanistic Prediction of Oral Drug Absorption},
  author={Masoud Jamei and David B. Turner and Jiansong Yang and Sibylle Neuhoff and Sebastian Polak and Amin Rostami-Hodjegan and Geoffrey T. Tucker},
  journal={The AAPS Journal},
  year={2009},
  volume={11},
  pages={225-237}
}
The bioavailability of drugs from oral formulations is influenced by many physiological factors including gastrointestinal fluid composition, pH and dynamics, transit and motility, and metabolism and transport, each of which may vary with age, gender, race, food, and disease. Therefore, oral bioavailability, particularly of poorly soluble and/or poorly permeable compounds and those that are extensively metabolized, often exhibits a high degree of inter- and intra-individual variability. While… CONTINUE READING
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