Poorly differentiated breast carcinoma is associated with increased expression of the human polycomb group EZH2 gene.

@article{Raaphorst2003PoorlyDB,
  title={Poorly differentiated breast carcinoma is associated with increased expression of the human polycomb group EZH2 gene.},
  author={Frank M. Raaphorst and Chris J L M Meijer and Elly Fieret and Tjasso Blokzijl and Ellen C. M. Mommers and Horst Buerger and Jens Packeisen and Richard G. A. B. Sewalt and Arie P. Otte and Paul J van Diest},
  journal={Neoplasia},
  year={2003},
  volume={5 6},
  pages={481-8}
}
Polycomb group (PcG) genes contribute to the maintenance of cell identity, cell cycle regulation, and oncogenesis. We describe the expression of five PcG genes (BMI-1, RING1, HPC1, HPC2, and EZH2) innormal breast tissues, invasive breast carcinomas, and their precursors. Members of the HPC-HPH/PRC1 PcG complex, including BMI-1, RING1, HPC1, and HPC2, were detected in normal resting and cycling breast cells. The EED-EZH/PRC2 PcG complex protein EZH2 was only found in rare cycling cells, whereas… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 96 extracted citations

Similar Papers

Loading similar papers…