Poor transcript‐protein correlation in the brain: negatively correlating gene products reveal neuronal polarity as a potential cause

@article{Moritz2019PoorTC,
  title={Poor transcript‐protein correlation in the brain: negatively correlating gene products reveal neuronal polarity as a potential cause},
  author={Christian P. Moritz and Timo M{\"u}hlhaus and Stefan Tenzer and Thomas Schulenborg and Eckhard Friauf},
  journal={Journal of Neurochemistry},
  year={2019},
  volume={149}
}
Transcription, translation, and turnover of transcripts and proteins are essential for cellular function. The contribution of those factors to protein levels is under debate, as transcript levels and cognate protein levels do not necessarily correlate due to regulation of translation and protein turnover. Here we propose neuronal polarity as a third factor that is particularly evident in the CNS, leading to considerable distances between somata and axon terminals. Consequently, transcript… Expand
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