Poor relevance of a lymphocyte proliferation assay in lamotrigine-induced Stevens-Johnson syndrome or toxic epidermal necrolysis.

@article{Tang2012PoorRO,
  title={Poor relevance of a lymphocyte proliferation assay in lamotrigine-induced Stevens-Johnson syndrome or toxic epidermal necrolysis.},
  author={Yong Hua Tang and Maja Mockenhaupt and Andrew Henry and M Bounoua and Luigi Naldi and Sabine le Gouvello and Armand Bensussan and Jean Claude Roujeau},
  journal={Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology},
  year={2012},
  volume={42 2},
  pages={248-54}
}
BACKGROUND Prior use of 'lymphocyte transformation test' (LTT) in Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) provided conflicting results, possibly dependent on sampling dates (acute vs. late). OBJECTIVE Evaluation of LTT in patients with SJS or TEN who reacted to lamotrigine (LTG). In a small subgroup we explored the possible role of regulatory T cells (T-reg). METHODS Acute phase samples (9) and post-recovery samples (14) from cases of SJS or TEN to LTG were… CONTINUE READING

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Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology • 2011

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