Poor relationship between arterial [lactate] and leg net release during exercise at 4,300 m altitude.

@article{Brooks1998PoorRB,
  title={Poor relationship between arterial [lactate] and leg net release during exercise at 4,300 m altitude.},
  author={George A. Brooks and Eugene E Wolfel and Gail E. Butterfield and Allen Cymerman and Amy C Roberts and Robert S. Mazzeo and John R T Reeves},
  journal={American journal of physiology. Regulatory, integrative and comparative physiology},
  year={1998},
  volume={275 4},
  pages={R1192-R1201}
}
We evaluated the hypotheses that on acute exposure to hypobaric hypoxia, sympathetic stimulation leads to augmented muscle lactate production and circulating [lactate] through a β-adrenergic mechanism and that β-adrenergic adaptation to chronic hypoxia is responsible for the blunted exercise lactate response after acclimatization to altitude. Five control and 6 β-blocked men were studied during rest and exercise at sea level (SL), on acute exposure to 4,300 m (A1), and after a 3-wk sojourn at… CONTINUE READING

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