Poor prognosis in warfarin-associated intracranial hemorrhage despite anticoagulation reversal.

@article{Dowlatshahi2012PoorPI,
  title={Poor prognosis in warfarin-associated intracranial hemorrhage despite anticoagulation reversal.},
  author={Dar Dowlatshahi and K. Scott Butcher and Negar Asdaghi and Susan N Nahirniak and Manya L Bernbaum and Antonio Giulivi and Jason K. Wasserman and Man-Chiu Poon and Shelagh B Coutts},
  journal={Stroke},
  year={2012},
  volume={43 7},
  pages={1812-7}
}
BACKGROUND AND PURPOSE Anticoagulant-associated intracranial hemorrhage (aaICH) presents with larger hematoma volumes, higher risk of hematoma expansion, and worse outcome than spontaneous intracranial hemorrhage. Prothrombin complex concentrates (PCCs) are indicated for urgent reversal of anticoagulation after aaICH. Given the lack of randomized controlled trial evidence of efficacy, and the potential for thrombotic complications, we aimed to determine outcomes in patients with aaICH treated… CONTINUE READING
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