Poor predictive value of serum creatinine for renal allograft loss.

@article{Kaplan2003PoorPV,
  title={Poor predictive value of serum creatinine for renal allograft loss.},
  author={Bruce Kaplan and Jesse D. Schold and Herwig-Ulf Meier-Kriesche},
  journal={American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons},
  year={2003},
  volume={3 12},
  pages={1560-5}
}
Both medical care and pharmaceutical development have led to an increase in expected graft and patient survival for patients who undergo renal transplantation. From a research perspective, it has become increasingly difficult to study the efficacy of new therapies using traditional 'hard' endpoints. In reaction to this dilemma, the transplant community has sought a surrogate endpoint. A natural candidate for a surrogate marker for graft loss that has been proposed is renal function (serum… CONTINUE READING