Poor diagnostic accuracy of commercial antibody-based assays for the diagnosis of acute Chikungunya infection.

@article{Blacksell2011PoorDA,
  title={Poor diagnostic accuracy of commercial antibody-based assays for the diagnosis of acute Chikungunya infection.},
  author={Stuart D Blacksell and Ampai Tanganuchitcharnchai and Richard G Jarman and Robert V Gibbons and Daniel H Paris and Mark E S Bailey and Nicholas P J Day and Ranjan Premaratna and David G Lalloo and Hithanadura Janaka de Silva},
  journal={Clinical and vaccine immunology : CVI},
  year={2011},
  volume={18 10},
  pages={1773-5}
}
A Sri Lankan fever cohort (n = 292 patients; 17.8% prevalence) was used to assess two standard diagnostic Chikungunya IgM tests. The immunochromatographic test (ICT) acute sample sensitivity (SN) was 1.9 to 3.9%, and specificity (SP) was 92.5 to 95.0%. The enzyme-linked immunosorbent assay (ELISA) gave an acute sample SN of 3.9% and an SP of 92.5% and a… CONTINUE READING