Poor allostimulatory function of liver plasmacytoid DC is associated with pro-apoptotic activity, dependent on regulatory T cells.

@article{Tokita2008PoorAF,
  title={Poor allostimulatory function of liver plasmacytoid DC is associated with pro-apoptotic activity, dependent on regulatory T cells.},
  author={Daisuke Tokita and Tina L. Sumpter and Giorgio Raimondi and Alan F. Zahorchak and Zhiliang Wang and Atsunori Nakao and George V Mazariegos and Masanori Abe and Angus W Thomson},
  journal={Journal of hepatology},
  year={2008},
  volume={49 6},
  pages={1008-18}
}
BACKGROUND/AIMS The liver is comparatively rich in plasmacytoid (p) dendritic cells (DC), - innate immune effector cells that are also thought to play key roles in the induction and regulation of adaptive immunity. METHODS Liver and spleen pDC were purified from fms-like tyrosine kinase ligand-treated control or lipopolysaccharide-injected C57BL/10 mice. Flow cytometric and molecular biologic assays were used to characterize their function and interaction with naturally occurring regulatory T… CONTINUE READING

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