Poor Correlation Between Clinical Disease Activity and Mucosal Inflammation, and the Role of Psychological Comorbidity, in Inflammatory Bowel Disease

@article{Gracie2016PoorCB,
  title={Poor Correlation Between Clinical Disease Activity and Mucosal Inflammation, and the Role of Psychological Comorbidity, in Inflammatory Bowel Disease},
  author={David J Gracie and Christopher Williams and R. M. Sood and Saqib Mumtaz and Mohammed H Bholah and Peter John Hamlin and Alexander Charles Ford},
  journal={The American Journal of Gastroenterology},
  year={2016},
  volume={111},
  pages={541-551}
}
OBJECTIVES:There is a move toward patient-reported outcome measures as end points in clinical trials of novel therapies for inflammatory bowel disease (IBD). However, the association between patient-reported symptoms and mucosal inflammation, and the influence of psychological factors, remains unclear. We examined this in a secondary care population.METHODS:Validated patient-reported disease activity indices were used to define clinically active disease in a cohort of 356 patients with… CONTINUE READING
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