Pooling strategies to reduce the cost of HIV-1 RNA load monitoring in a resource-limited setting.

@article{Zyl2011PoolingST,
  title={Pooling strategies to reduce the cost of HIV-1 RNA load monitoring in a resource-limited setting.},
  author={Gert Van Zyl and Wolfgang Preiser and S Potschka and A T Lundershausen and Richard Haubrich and Don Smith},
  journal={Clinical infectious diseases : an official publication of the Infectious Diseases Society of America},
  year={2011},
  volume={52 2},
  pages={
          264-70
        }
}
BACKGROUND Quantitative human immunodeficiency virus (HIV) RNA load testing surpasses CD4 cell count and clinical monitoring in detecting antiretroviral therapy (ART) failure; however, its cost can be prohibitive. Recently, the use of pooling strategies with a clinically appropriate viral load threshold was shown to be accurate and efficient for monitoring when the prevalence of virologic failure is low. METHODS We used laboratory request form information to identify specimens with a low… CONTINUE READING