Pooled analysis of safety and efficacy of oxaliplatin plus fluorouracil/leucovorin administered bimonthly in elderly patients with colorectal cancer.

@article{Goldberg2006PooledAO,
  title={Pooled analysis of safety and efficacy of oxaliplatin plus fluorouracil/leucovorin administered bimonthly in elderly patients with colorectal cancer.},
  author={Richard M. Goldberg and Isabelle Tabah-Fisch and Harry Bleiberg and Aimery de Gramont and Christophe Tournigand and Thierry Andr{\'e} and Mace L. Rothenberg and Erin H. Green and Daniel J. Sargent},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  year={2006},
  volume={24 25},
  pages={4085-91}
}
PURPOSE Oxaliplatin, fluorouracil, and leucovorin are commonly used to treat advanced and resected colorectal cancer. This analysis compares the safety and efficacy of oxaliplatin plus fluorouracil/leucovorin administered bimonthly (FOLFOX4) in patients age younger than and at least 70 years. PATIENTS AND METHODS This retrospective analysis included 3,742 colorectal cancer patients (614 age > or = 70) from four clinical trials testing FOLFOX4 in the adjuvant, first-, and second-line settings… CONTINUE READING
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