Pontine carbachol elicits multiple rapid eye movement sleep-like neural events in urethane-anaesthetized rats.

@article{Horner1999PontineCE,
  title={Pontine carbachol elicits multiple rapid eye movement sleep-like neural events in urethane-anaesthetized rats.},
  author={Richard L Horner and Leszek Kubin},
  journal={Neuroscience},
  year={1999},
  volume={93 1},
  pages={215-26}
}
Microinjection of a cholinergic agonist, carbachol, into the pontine reticular formation of chronically instrumented intact or acutely decerebrate rats and cats has been used extensively to study rapid eye movement sleep mechanisms. In this study, we sought to develop a reduced carbachol model of rapid eye movement sleep-like neural events exhibiting multiple physiological markers of this state, and allowing for the use of invasive electrophysiological techniques. Accordingly, we investigated… CONTINUE READING