Pomolic acid, triterpenoid isolated from Licania pittieri, as competitive antagonist of ADP-induced aggregation of human platelets.

@article{AlvaradoCastillo2012PomolicAT,
  title={Pomolic acid, triterpenoid isolated from Licania pittieri, as competitive antagonist of ADP-induced aggregation of human platelets.},
  author={Claudia Alvarado-Castillo and Omar Estrada and Edilmo Carvajal},
  journal={Phytomedicine : international journal of phytotherapy and phytopharmacology},
  year={2012},
  volume={19 6},
  pages={484-7}
}
Pomolic acid (PA), triterpenoid isolated from Licania pittieri, has previously shown a potent ability to inhibit adenosine diphosphate (ADP)- and epinephrine-induced human platelet aggregation. To investigate whether PA could be an antagonist of ADP-activated receptors of human platelets (P2Y(1) and P2Y(12)), pharmacological studies were conducted to examining its ability to modulate the platelet shape change induced by a selective P2Y(1) receptor agonist MRS2365 and also the nature of its… CONTINUE READING

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