Pomegranate juice inhibits sulfoconjugation in Caco-2 human colon carcinoma cells.

  title={Pomegranate juice inhibits sulfoconjugation in Caco-2 human colon carcinoma cells.},
  author={Ayako Saruwatari and Shigeaki Okamura and Yoko Nakajima and Yuji Narukawa and Tadahiro Takeda and Hiroomi Tamura},
  journal={Journal of medicinal food},
  volume={11 4},
Several fruit juices have been reported to cause food-drug interactions, mainly affecting cytochrome P450 activity; however, little is known about the effects of fruit juices on conjugation reactions. Among several fruit juices tested (apple, peach, orange, pineapple, grapefruit, and pomegranate), pomegranate juice potently inhibited the sulfoconjugation of 1-naphthol in Caco-2 cells. This inhibition was both dose- and culture time-dependent, with a 50% inhibitory concentration (IC(50)) value… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 10 extracted citations


Publications referenced by this paper.
Showing 1-10 of 25 references

Beneficial effects of pomegranate juice on oxidationsensitive genes and endothelial nitric oxide synthetase activity at sites of perturbed shear stress

  • F De Nigris, S Williams-Ignarro, +8 authors C Napoli
  • Proc Natl Acad Sci U S A 2005;102:4896–4901
  • 2005

Why a pomegranate ?

  • A Malik, F Afaq, S Sarfaeaz, VM Adhami, DN Syed, H Mukhtar
  • BMJ
  • 2005

Why a pomegranate? BMJ 2005;321:1153–1154

  • P Langley
  • 2005

Effect of herbal teas on conjugation reactions in a human colon carcinoma cell line, Caco-2

  • S Okamura, H Tamura
  • J Health Sci 2004;50:189–192
  • 2004

Similar Papers

Loading similar papers…