Pomegranate juice inhibits sulfoconjugation in Caco-2 human colon carcinoma cells.

@article{Saruwatari2008PomegranateJI,
  title={Pomegranate juice inhibits sulfoconjugation in Caco-2 human colon carcinoma cells.},
  author={Ayako Saruwatari and Shigeaki Okamura and Yoko Nakajima and Yuji Narukawa and Tadahiro Takeda and Hiroomi Tamura},
  journal={Journal of medicinal food},
  year={2008},
  volume={11 4},
  pages={623-8}
}
Several fruit juices have been reported to cause food-drug interactions, mainly affecting cytochrome P450 activity; however, little is known about the effects of fruit juices on conjugation reactions. Among several fruit juices tested (apple, peach, orange, pineapple, grapefruit, and pomegranate), pomegranate juice potently inhibited the sulfoconjugation of 1-naphthol in Caco-2 cells. This inhibition was both dose- and culture time-dependent, with a 50% inhibitory concentration (IC(50)) value… CONTINUE READING

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