Pomegranate juice and punicalagin attenuate oxidative stress and apoptosis in human placenta and in human placental trophoblasts.

@article{Chen2012PomegranateJA,
  title={Pomegranate juice and punicalagin attenuate oxidative stress and apoptosis in human placenta and in human placental trophoblasts.},
  author={Baosheng Chen and Methodius G. Tuuli and Mark S. Longtine and Joong Sik Shin and Russell Lawrence and Terrie E. Inder and D Michael Nelson},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2012},
  volume={302 9},
  pages={E1142-52}
}
The human placenta is key to pregnancy outcome, and the elevated oxidative stress present in many complicated pregnancies contributes to placental dysfunction and suboptimal pregnancy outcomes. We tested the hypothesis that pomegranate juice, which is rich in polyphenolic antioxidants, limits placental trophoblast injury in vivo and in vitro. Pregnant women with singleton pregnancies were randomized at 35∼38 wk gestation to 8 oz/day of pomegranate juice or apple juice (placebo) until the time… CONTINUE READING