Pomegranate fruit extract impairs invasion and motility in human breast cancer.

  title={Pomegranate fruit extract impairs invasion and motility in human breast cancer.},
  author={Gazala Naaz Khan and Michael A Gorin and Devin T. Rosenthal and Quintin Pan and Li Wei Bao and Zhi Fen Wu and Robert A. Newman and Alison D Pawlus and Peiying Yang and Ephraim Philip Lansky and Sof{\'i}a D. Merajver},
  journal={Integrative cancer therapies},
  volume={8 3},
PURPOSE Pomegranate fruit extracts (PFEs) possess polyphenolic and other compounds with antiproliferative, pro-apoptotic and anti-inflammatory effects in prostate, lung, and other cancers. Because nuclear transcription factor-kB (NF-kB) is known to regulate cell survival, proliferation, tumorigenesis, and inflammation, it was postulated that PFEs may exert anticancer effects at least in part by modulating NF-kB activity. EXPERIMENTAL DESIGN The authors investigated the effect of a novel… CONTINUE READING
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