Pomegranate-Derived Polyphenols Reduce Reactive Oxygen Species Production via SIRT3-Mediated SOD2 Activation

  title={Pomegranate-Derived Polyphenols Reduce Reactive Oxygen Species Production via SIRT3-Mediated SOD2 Activation},
  author={Chong Zhao and Takenori Sakaguchi and Kosuke Fujita and Hideyuki Ito and Norihisa Nishida and Akifumi Nagatomo and Yukimasa Tanaka-Azuma and Yoshinori Katakura},
  booktitle={Oxidative medicine and cellular longevity},
Pomegranate-derived polyphenols are expected to prevent life-style related diseases. In this study, we evaluated the ability of 8 pomegranate-derived polyphenols, along with other polyphenols, to augment SIRT3, a mammalian SIR2 homolog localized in mitochondria. We established a system for screening foods/food ingredients that augment the SIRT3 promoter in Caco-2 cells and identified 3 SIRT3-augmenting pomegranate-derived polyphenols (eucalbanin B, pomegraniin A, and eucarpanin T1). Among them… CONTINUE READING
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