Pomegranate (Punica granatum) pure chemicals show possible synergistic inhibition of human PC-3 prostate cancer cell invasion across Matrigel™
@article{Lansky2005PomegranateG, title={Pomegranate (Punica granatum) pure chemicals show possible synergistic inhibition of human PC-3 prostate cancer cell invasion across Matrigel{\texttrademark}}, author={Ephraim S. P. Lansky and Gregory M. Harrison and Paul Froom and Wen Guo Jiang}, journal={Investigational New Drugs}, year={2005}, volume={23}, pages={121-122} }
SummaryFour pure chemicals, ellagic acid (E), caffeic acid (C), luteolin (L) and punicic acid (P), all important components of the aqueous compartments or oily compartment of pomegranate fruit (Punica granatum), and each belonging to different representative chemical classes and showing known anticancer activities, were tested as potential inhibitors of in vitro invasion of human PC-3 prostate cancer cells in an assay employing Matrigel™ artificial membranes. All compounds significantly…
168 Citations
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References
SHOWING 1-7 OF 7 REFERENCES
Possible synergistic prostate cancer suppression by anatomically discrete pomegranate fractions
- BiologyInvestigational New Drugs
- 2004
The results suggest vertical as well as the usual horizontal strategies for discovering pharmacological actives in plants might act synergistically against proliferation, metastatic potential, and phosholipase A2 expression of human prostate cancer cells in vitro.
Rapid dereplication of estrogenic compounds in pomegranate (Punica granatum) using on-line biochemical detection coupled to mass spectrometry.
- BiologyPhytochemistry
- 2004
Antioxidant and eicosanoid enzyme inhibition properties of pomegranate seed oil and fermented juice flavonoids.
- Chemistry, MedicineJournal of ethnopharmacology
- 1999
Regulation of the Expression of E-Cadherin on Human Cancer Cells by γ-Linolenic Acid (GLA)
- Biology, Medicine
- 1995
Treatment of cells with GLA for 24 h increased the expression of E-cadherin in lung, colon, breast, melanoma, and liver cancer cells, but not in endothelial cells and fibroblasts and the increased expression was correlated with reduced in vitro invasion and increased aggregation, indicating that the increased E- cadaverin expression induced by GLA was biologically active.
Regulation of the expression of E-cadherin on human cancer cells by gamma-linolenic acid (GLA).
- Biology, MedicineCancer research
- 1995
Treatment of cells with GLA for 24 h increased the expression of E-cadherin in lung, colon, breast, melanoma, and liver cancer cells, but not in endothelial cells and fibroblasts, and the increased expression was correlated with reduced in vitro invasion and increased aggregation, indicating that the increased E- cadaverin expression induced by GLA was biologically active.
High-performance liquid chromatographic determination with photodiode array detection of ellagic acid in fresh and processed fruits.
- Chemistry, MedicineJournal of chromatography. A
- 2000
Determination of Phenolic Compounds by HPLC
- Chemistry
- 1982
Details are given of a procedure for separation and identification of phenolic compounds in aqueous solution by high-performance liquid chromatography. It can also be applied to non-aqueous samples…