Pom1 gradient buffering through intermolecular auto-phosphorylation

@inproceedings{Hersch2015Pom1GB,
  title={Pom1 gradient buffering through intermolecular auto-phosphorylation},
  author={Micha Hersch and Olivier Hachet and Sascha Dalessi and Pranav Ullal and Payal Bhatia and Sven Bergmann and Sophie G. Martin},
  booktitle={Molecular systems biology},
  year={2015}
}
Concentration gradients provide spatial information for tissue patterning and cell organization, and their robustness under natural fluctuations is an evolutionary advantage. In rod-shaped Schizosaccharomyces pombe cells, the DYRK-family kinase Pom1 gradients control cell division timing and placement. Upon dephosphorylation by a Tea4-phosphatase complex, Pom1 associates with the plasma membrane at cell poles, where it diffuses and detaches upon auto-phosphorylation. Here, we demonstrate that… CONTINUE READING
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