Polyvalent vaccines for optimal coverage of potential T-cell epitopes in global HIV-1 variants

@article{Fischer2007PolyvalentVF,
  title={Polyvalent vaccines for optimal coverage of potential T-cell epitopes in global HIV-1 variants},
  author={Will Fischer and Simon Perkins and James Theiler and Tanmoy Bhattacharya and Karina Yusim and Robert Funkhouser and Carla Kuiken and Barton Haynes and Norman L. Letvin and Bruce D. Walker and Beatrice H. Hahn and Bette T Korber},
  journal={Nature Medicine},
  year={2007},
  volume={13},
  pages={100-106}
}
HIV-1/AIDS vaccines must address the extreme diversity of HIV-1. We have designed new polyvalent vaccine antigens comprised of sets of 'mosaic' proteins, assembled from fragments of natural sequences via a computational optimization method. Mosaic proteins resemble natural proteins, and a mosaic set maximizes the coverage of potential T-cell epitopes (peptides of nine amino acids) for a viral population. We found that coverage of viral diversity using mosaics was greatly increased compared to… CONTINUE READING