Polyunsaturated lysophosphatidic acid as a potential asthma biomarker.

@article{Ackerman2016PolyunsaturatedLA,
  title={Polyunsaturated lysophosphatidic acid as a potential asthma biomarker.},
  author={S. J. Ackerman and Gye Young Park and John W Christman and Sharmilee M Nyenhuis and Evgeny Berdyshev and Viswanathan Natarajan},
  journal={Biomarkers in medicine},
  year={2016},
  volume={10 2},
  pages={123-35}
}
Lysophosphatidic acid (LPA), a lipid mediator in biological fluids and tissues, is generated mainly by autotaxin that hydrolyzes lysophosphatidylcholine to LPA and choline. Total LPA levels are increased in bronchoalveolar lavage fluid from asthmatic lung, and are strongly induced following subsegmental bronchoprovocation with allergen in subjects with allergic asthma. Polyunsaturated molecular species of LPA (C22:5 and C22:6) are selectively synthesized in the airways of asthma subjects… CONTINUE READING
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