Polyunsaturated fatty acids regulate Shiga toxin transport.

  title={Polyunsaturated fatty acids regulate Shiga toxin transport.},
  author={Bj\orn Spilsberg and Alicia Llorente and Kirsten Sandvig},
  journal={Biochemical and biophysical research communications},
  volume={364 2},
Shiga toxin (Stx) is internalized by receptor-mediated endocytosis and transported retrogradely to the endoplasmic reticulum from where the enzymatically active part of the toxin is translocated to the cytosol. In this study, we have investigated the effect of polyunsaturated fatty acids (PUFA) on intoxication and retrograde transport of Stx. In HEp-2 cells, PUFA treatment inhibited Stx intoxication by a factor of 10. Moreover, both Stx internalization and endosome-to-Golgi transport were… CONTINUE READING

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