Polyunsaturated fatty acids of marine origin induce adiponectin in mice fed a high-fat diet

  title={Polyunsaturated fatty acids of marine origin induce adiponectin in mice fed a high-fat diet},
  author={Pavel Flachs and Vidya Mohamed-Ali and Olga Horakova and Martin Rossmeisl and Mohammad Javad Hosseinzadeh-Attar and Michal Hensler and Jana Rů{\vz}i{\vc}kov{\'a} and J{\'a}n Kopeck{\'y}},
Diets rich in n-3 polyunsaturated fatty acids, namely eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), protect against insulin resistance and obesity in rodents and increase insulin sensitivity in healthy humans. We tested whether the anti-diabetic effects of EPA and DHA involve enhanced production of the endogenous insulin sensitiser, adiponectin. We studied the effects, in an obesity-promoting high-fat diet, of partial replacement of vegetable oils by EPA/DHA concentrate (6% EPA… CONTINUE READING


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