Polyunsaturated fatty acids induce polarized submembranous F-actin aggregates and kill Entamoeba histolytica.

@article{Manna2013PolyunsaturatedFA,
  title={Polyunsaturated fatty acids induce polarized submembranous F-actin aggregates and kill Entamoeba histolytica.},
  author={Dipak Manna and Jaspreet Singh Grewal and Bidyut Sarkar and Sudipta Maiti and Anuradha Lohia},
  journal={Cytoskeleton},
  year={2013},
  volume={70 5},
  pages={260-8}
}
We have recently identified a novel galacto-glycerolipid (GGL) from the plant Oxalis corniculata that killed the human pathogen Entamoeba histolytica. In this study, we show that the anti-amoebic activity of GGL was due to the polyunsaturated fatty acid α-linolenic acid (C18:3 ) side chain. Treatment of α-linolenic acid to E. histolytica trophozoites disrupted the cytoskeletal network and led to polarization of F-actin at one end of the cells with prominent filopodial extensions. In addition… CONTINUE READING
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