Polyunsaturated fatty acids in the pathogenesis and treatment of multiple sclerosis

@article{Harbige2007PolyunsaturatedFA,
  title={Polyunsaturated fatty acids in the pathogenesis and treatment of multiple sclerosis},
  author={Laurence S. Harbige and Mohammad K. Sharief},
  journal={British Journal of Nutrition},
  year={2007},
  volume={98},
  pages={S46 - S53}
}
Epidemiological, biochemical, animal model and clinical trial data described in this overview strongly suggest that polyunsaturated fatty acids, particularly n-6 fatty acids, have a role in the pathogenesis and treatment of multiple sclerosis (MS). Data presented provides further evidence for a disturbance in n-6 fatty acid metabolism in MS. Disturbance of n-6 fatty acid metabolism and dysregulation of cytokines are shown to be linked and a “proof of concept clinical trial” further supports… Expand
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