Polyunsaturated fatty acids ameliorate hepatic steatosis in obese mice by SREBP-1 suppression.

  title={Polyunsaturated fatty acids ameliorate hepatic steatosis in obese mice by SREBP-1 suppression.},
  author={Motohiro Sekiya and Naoya Yahagi and Takashi Matsuzaka and Yuho Najima and Masanori Nakakuki and Ryozo Nagai and Shun Ishibashi and Jun-ichi Osuga and Nobuhiro Yamada and Hitoshi Shimano},
  volume={38 6},
Leptin-deficient ob/ob mice show many characteristics of obesity, including excess peripheral adiposity as well as severe hepatic steatosis, at least in part, due to increased hepatic lipogenesis. Polyunsaturated fatty acids (PUFAs) are not only ligands for peroxisome proliferator-activated receptor (PPAR) alpha but are also negative regulators of hepatic lipogenesis, which is thought to be mediated by the repression of sterol regulatory element-binding protein (SREBP)-1. We have previously… CONTINUE READING
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