Polyubiquitylation of histone H2B.

@article{Geng2008PolyubiquitylationOH,
  title={Polyubiquitylation of histone H2B.},
  author={Fuqiang Geng and W P Tansey},
  journal={Molecular biology of the cell},
  year={2008},
  volume={19 9},
  pages={
          3616-24
        }
}
Covalent modification of histones by ubiquitylation is a prominent epigenetic mark that features in a variety of chromatin-based events such as histone methylation, gene silencing, and repair of DNA damage. The prototypical example of histone ubiquitylation is that of histone H2B in Saccharomyces cerevisiae. In this case, attachment of ubiquitin to lysine 123 (K123) of H2B is important for regulation of both active and transcriptionally silent genes and participates in trans to signal… CONTINUE READING

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