Polyubiquitinated proteins, proteasome, and glycogen characterize the particle-rich cytoplasmic structure (PaCS) of neoplastic and fetal cells

@article{Necchi2014PolyubiquitinatedPP,
  title={Polyubiquitinated proteins, proteasome, and glycogen characterize the particle-rich cytoplasmic structure (PaCS) of neoplastic and fetal cells},
  author={Vittorio Necchi and Patrizia Sommi and Agostina Vitali and Alessandro Vanoli and Anna Savoia and Vittorio Ricci and Enrico Solcia},
  journal={Histochemistry and Cell Biology},
  year={2014},
  volume={141},
  pages={483-497}
}
A particle-rich cytoplasmic structure (PaCS) concentrating ubiquitin–proteasome system (UPS) components and barrel-like particles in clear, cytoskeleton- and organelle-free areas has recently been described in some neoplasms and in genetic or infectious diseases at risk of neoplasia. Ultrastructurally similar particulate cytoplasmic structures, interpreted as glycogen deposits, have previously been reported in clear-cell neoplasms and some fetal tissues. It remains to be investigated whether… CONTINUE READING