Polyubiquitin chains: functions, structures, and mechanisms

  • W. Li, Y. Ye
  • Published 2008 in Cellular and Molecular Life Sciences

Abstract

Ubiquitin is a highly conserved 76-aminoacid polypeptide that is found throughout the eukaryotic kingdom. The covalent conjugation of ubiquitin (often in the form of a polymer) to substrates governs a variety of biological processes ranging from proteolysis to DNA damage tolerance. The functional flexibility of this post-translational modification has its… (More)
DOI: 10.1007/s00018-008-8090-6

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