Polytope DNA vaccine development against hepatitis C virus: a streamlined approach from in silico design to in vitro and primary in vivo analyses in BALB/c mice.

@article{Memarnejadian2009PolytopeDV,
  title={Polytope DNA vaccine development against hepatitis C virus: a streamlined approach from in silico design to in vitro and primary in vivo analyses in BALB/c mice.},
  author={Arash Memarnejadian and Farzin Roohvand and Arash Arashkia and Sima Rafati and Mohammad Ali Shokrgozar},
  journal={Protein and peptide letters},
  year={2009},
  volume={16 7},
  pages={842-50}
}
For chronic viral infections like Hepatitis C, CD8-CTLs have emerged as important protective tools. Hence, isolated dominant epitopes arranged as polytope DNA or peptide vaccines represent a promising approach. However, because of controversial rules governing the polytope construction and epitope processing, proper design and primary analysis of such… CONTINUE READING