Polysurgery of cell sheet grafts overcomes diffusion limits to produce thick, vascularized myocardial tissues.

@article{Shimizu2006PolysurgeryOC,
  title={Polysurgery of cell sheet grafts overcomes diffusion limits to produce thick, vascularized myocardial tissues.},
  author={Tatsuya Shimizu and Hidekazu Sekine and Joseph Yang and Yuki Isoi and Masayuki Yamato and Akihiko Kikuchi and Eiji Kobayashi and T. Okano},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={2006},
  volume={20 6},
  pages={708-10}
}
Recently, the field of tissue engineering has progressed rapidly, but poor vascularization remains a major obstacle in bioengineering cell-dense tissues, limiting the viable size of constructs due to hypoxia, nutrient insufficiency, and waste accumulation. Therefore, new technologies for fabricating functional tissues with a well-organized vasculature are required. In the present study, neonatal rat cardiomyocytes were harvested as intact sheets from temperature-responsive culture dishes and… CONTINUE READING
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