Polystyrene nanoplastic induces ROS production and affects the MAPK-HIF-1/NFkB-mediated antioxidant system in Daphnia pulex.

  title={Polystyrene nanoplastic induces ROS production and affects the MAPK-HIF-1/NFkB-mediated antioxidant system in Daphnia pulex.},
  author={Zhiquan Liu and Youhui Huang and Yang Jiao and Qiang Chen and Donglei Wu and Ping Yu and Yiming Li and Mingqi Cai and Yunlong Zhao},
  journal={Aquatic toxicology},

Effects of nanoplastics on antioxidant and immune enzyme activities and related gene expression in juvenile Macrobrachium nipponense.

antioxidants The Pressing Issue of Micro- and Nanoplastic Contamination: Profiling the Reproductive Alterations Mediated by Oxidative Stress

Recent studies on the effects of MPs/NPs on the reproductive health in aquatic and terrestrial organisms of both sexes are reviewed, focusing on the role of OS and the antioxidant defence system failure as the main underlying mechanisms.

Polystyrene nanoplastics exacerbated lipopolysaccharide‐induced necroptosis and inflammation via the ROS/MAPK pathway in mice spleen

It is demonstrated that PS‐NPs promoted LPS‐induced spleen necroptosis and inflammation in mice through the ROS/MAPK pathway and ROS inhibitor N‐Acetyl‐L‐cysteine (NAC) significantly inhibited the activation of the mitogen‐activated protein kinase (MAPK) signaling pathway caused by co‐treatment of PS‐nPs and LPS, reducing necropsies and inflammation.



The role of Nrf2 and MAPK pathways in PFOS-induced oxidative stress in zebrafish embryos.

It is found that coexposure with sulforaphane, an Nrf2 activator, could significantly protect against PFOS-induced ROS generation, whereas inhibition of MAPKs did not exhibit significant effects on PFos-induced HO-1 gene expression and ROS production.

Adverse effects of microplastics and oxidative stress-induced MAPK/Nrf2 pathway-mediated defense mechanisms in the marine copepod Paracyclopina nana

This study provides the first insight into the mode of action in terms of microplastic-induced oxidative stress and related signaling pathways in P. nana, and proposes an adverse outcome pathway for microplastics exposure that covers molecular and individual levels.

Microplastic Size-Dependent Toxicity, Oxidative Stress Induction, and p-JNK and p-p38 Activation in the Monogonont Rotifer (Brachionus koreanus).

In vitro tests revealed that antioxidant-related enzymes and MAPK signaling pathways were significantly activated in response to microplastic exposure in a size-dependent manner, suggesting that 6-μm microbeads are more effectively egested from B. koreanus than 0.05- or 0.5- μm microBeads.

Oxidative stress-related PMK-1 P38 MAPK activation as a mechanism for toxicity of silver nanoparticles to reproduction in the nematode Caenorhabditis elegans.

It is suggested that oxidative stress is an important mechanism of AgNP‐induced reproduction toxicity in C. elegans, and that PMK‐1 p38 MAPK plays an important role in it.