Polystyrene nanoparticle trafficking across MDCK-II.

  title={Polystyrene nanoparticle trafficking across MDCK-II.},
  author={Farnoosh Fazlollahi and Susanne Angelow and Nazanin R Yacobi and Ronald R. Marchelletta and Alan S L Yu and Sarah F Hamm-Alvarez and Zea Borok and Kwang-Jin Kim and Edward D Crandall},
  journal={Nanomedicine : nanotechnology, biology, and medicine},
  volume={7 5},
Polystyrene nanoparticles (PNP) cross rat alveolar epithelial cell monolayers via non-endocytic transcellular pathways. To evaluate epithelial cell type-specificity of PNP trafficking, we studied PNP flux across Madin Darby canine kidney cell II monolayers (MDCK-II). The effects of calcium chelation (EGTA), energy depletion (sodium azide (NaN(3)) or decreased temperature), and endocytosis inhibitors methyl-β-cyclodextrin (MBC), monodansylcadaverine and dynasore were determined. Amidine-modified… CONTINUE READING


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