Polyspecific organic cation transporters and their biomedical relevance in kidney.

  title={Polyspecific organic cation transporters and their biomedical relevance in kidney.},
  author={Hermann Koepsell},
  journal={Current opinion in nephrology and hypertension},
  volume={22 5},
PURPOSE OF REVIEW Secretion and reabsorption of organic cations in kidney is mediated by polyspecific transporters with broadly overlapping substrate specificity. Knowledge concerning function, transported compounds, clinical impact of mutations in the transporters and drug-drug interactions is rapidly increasing. Recent research concerning properties of these transporters and their clinical significance for nephrology is summarized. RECENT FINDINGS Recent data showed that the organic cation… CONTINUE READING
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