Polyspecific, antiviral immune response distinguishes multiple sclerosis and neuromyelitis optica.

  title={Polyspecific, antiviral immune response distinguishes multiple sclerosis and neuromyelitis optica.},
  author={Sven Jarius and Diego Franciotta and Roberto Bergamaschi and Sebastian Rauer and K. P. Wandinger and H Felicitas Petereit and Martin Maurer and Hayrettin Tumani and Angela Vincent and Peter Eichhorn and Brigitte T. Wildemann and Manfred T. Wick and Raymond Voltz},
  journal={Journal of neurology, neurosurgery, and psychiatry},
  volume={79 10},
BACKGROUND A polyspecific, intrathecal humoral immune response against neurotropic viruses such as measles, rubella and varicella zoster virus (MRZ reaction, MRZR) is present in 80-100% of patients with multiple sclerosis (MS), but has not to date been evaluated in patients with neuromyelitis optica (NMO). AIMS To evaluate whether MRZR distinguishes NMO and MS. METHODS 20 patients with NMO and 42 with MS were included. The intrathecal synthesis of antibodies against measles, rubella and… CONTINUE READING

From This Paper

Figures, tables, and topics from this paper.


Publications citing this paper.
Showing 1-10 of 38 extracted citations

Neuromyelitis optica pathogenesis and aquaporin 4

Journal of Neuroinflammation • 2008
View 13 Excerpts
Highly Influenced

Biomarkers of treatment response in multiple sclerosis.

Expert review of neurotherapeutics • 2014
View 7 Excerpts
Highly Influenced


Publications referenced by this paper.
Showing 1-10 of 25 references

Neuromyelitis optica.

Current treatment options in neurology • 2008

Similar Papers

Loading similar papers…