Polysomy 8 defines a clinico-cytogenetic entity representing a subset of myeloid hematologic malignancies associated with a poor prognosis: report on a cohort of 12 patients and review of 105 published cases.

@article{Beyer2005Polysomy8D,
  title={Polysomy 8 defines a clinico-cytogenetic entity representing a subset of myeloid hematologic malignancies associated with a poor prognosis: report on a cohort of 12 patients and review of 105 published cases.},
  author={Val{\'e}rie Beyer and Dominique Muehlematter and Val{\'e}rie Parlier and Christine Cabrol and Sandrine Bougeon-Mamin and Max Solenthaler and Andreas R Tobler and Paul Pugin and Michael Gregor and Felicitas Hitz and Urs Hess and Bernard Chapuis and France Laurencet and Urs Schanz and P Schmidt and Guy van Melle and Martine Jotterand},
  journal={Cancer genetics and cytogenetics},
  year={2005},
  volume={160 2},
  pages={97-119}
}
Tetrasomy, pentasomy, and hexasomy 8 (polysomy 8) are relatively rare compared to trisomy 8. Here we report on a series of 12 patients with acute myeloid leukemia (AML), myelodysplastic syndrome (MDS), or myeloproliferative disorder (MPD) associated with polysomy 8 as detected by conventional cytogenetics and fluorescence in situ hybridization (FISH). In an attempt to better characterize the clinical and hematological profile of this cytogenetic entity, our data were combined with those of 105… CONTINUE READING