Polysomy 17 and HER-2 amplification: true, true, and unrelated.


Approximately 25% of breast cancers overexpress the human epidermal growth factor receptor 2 (HER-2) protein, usually as a result of high copy number of its gene (amplification) on chromosome 17q12-21. HER-2 signaling promotes cell proliferation, and overexpression or gene amplification are associated with poor prognosis. In view of this, trastuzumab… (More)
DOI: 10.1200/JCO.2008.17.2684