Polysialyltransferase overexpression in Schwann cells mediates different effects during peripheral nerve regeneration.

  title={Polysialyltransferase overexpression in Schwann cells mediates different effects during peripheral nerve regeneration.},
  author={Julia Jungnickel and Matthias Eckhardt and Kirsten Haastert-Talini and Peter Claus and Paul Bronzlik and Esther Lipokatic-Takacs and Helena Maier and Volkmar Gieselmann and Claudia B. Grothe},
  volume={22 1},
The polysialic acid (PSA) moiety of the neural cell adhesion molecule (NCAM) has been shown to support dynamic changes underlying peripheral nerve regeneration. Using transgenic mice expressing polysialyltransferase ST8SiaIV under control of a glial-specific (proteolipid protein, PLP) promoter (PLP-ST8SiaIV-transgenic mice), we tested the hypothesis that permanent synthesis of PSA in Schwann cells impairs functional recovery of lesioned peripheral nerves. After sciatic nerve crush… CONTINUE READING


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