Polysialyltransferase: a new target in metastatic cancer.

@article{Falconer2012PolysialyltransferaseAN,
  title={Polysialyltransferase: a new target in metastatic cancer.},
  author={R. Falconer and R. Errington and S. Shnyder and P. Smith and L. Patterson},
  journal={Current cancer drug targets},
  year={2012},
  volume={12 8},
  pages={
          925-39
        }
}
Polysialic acid (polySia) is a carbohydrate polymer critical for neuronal cell migration and axon pathfinding in embryonic development. Besides brain regions requiring persistent neuronal plasticity, polySia is essentially absent from the adult body. However, polySia is aberrantly re-expressed on many tumours, where it decorates the surface of NCAM (neuronal cell adhesion molecule) and modulates cell adhesion, migration and invasion. PolySia-NCAM expression is strongly associated with poor… Expand
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