Polysialylated neuropilin-2 is expressed on the surface of human dendritic cells and modulates dendritic cell-T lymphocyte interactions.

@article{Curreli2007PolysialylatedNI,
  title={Polysialylated neuropilin-2 is expressed on the surface of human dendritic cells and modulates dendritic cell-T lymphocyte interactions.},
  author={Sabrina Curreli and Zita Arany and Rita Gerardy-Schahn and Dean A Mann and Nicholas M. Stamatos},
  journal={The Journal of biological chemistry},
  year={2007},
  volume={282 42},
  pages={30346-56}
}
Polysialic acid (PSA) is a unique linear homopolymer of alpha2,8-linked sialic acid that has been identified as a posttranslational modification on only five mammalian proteins. Studied predominantly on neural cell adhesion molecule (NCAM) during development of the vertebrate nervous system, PSA modulates cell interactions mediated by NCAM and other adhesion molecules. An isoform of NCAM (CD56) on natural killer (NK) cells is the only protein known to be polysialylated in cells of the immune… CONTINUE READING
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